Escherichiacoli surface display for the selection of nanobodies
نویسندگان
چکیده
منابع مشابه
Escherichia coli surface display for the selection of nanobodies
Nanobodies (Nbs) are the smallest functional antibody fragments known in nature and have multiple applications in biomedicine or environmental monitoring. Nbs are derived from the variable segment of camelid heavy chain-only antibodies, known as VHH. For selection, libraries of VHH gene segments from naïve, immunized animals or of synthetic origin have been traditionally cloned in E. coli phage...
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15 صفحه اولConstruction of a Nanobodies Phage Display Library From an Escherichia coli Immunized Dromedary
Background: Diarrhea caused by Escherichia coli is a major cause of morbidity and mortality in young animals. Few treatment options are available, mainly antibiotic therapy increasingly limited by resistance to commonly used drugs.Objectives: The aim of this work was to develop immunotherapy based on the use of camel VHH antibody fragments, or nanobodies,...
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ژورنال
عنوان ژورنال: Microbial Biotechnology
سال: 2017
ISSN: 1751-7915,1751-7915
DOI: 10.1111/1751-7915.12819